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Ginkgolide - Wikipedia
Ginkgolides are biologically active terpenic lactones present in Ginkgo biloba. They are diterpenoids with 20-carbon skeletons, which are biosynthesized from geranylgeranyl pyrophosphate. [1]
The neuroprotective mechanisms of ginkgolides and bilobalide in ...
This review seeks to elucidate the neuroprotective effects and mechanisms of ginkgolides, especially GA and GB, and bilobalide in cerebral injury following ischemic strokes. The incidence and mortality of strokes have increased over the past three decades in China.
The neuroprotective mechanisms of ginkgolides and bilobalide in ...
The ginkgolides and bilobalide that constitute a critical part of EGb761 have demonstrated protective properties towards cerebral injury. Ginkgolides include Ginkgolide A (GA), Ginkgolide B (GB), Ginkgolide C (GC), Ginkgolide J (GJ), Ginkgolide K (GK), Ginkgolide L (GL), and Ginkgolide M (GM).
Ginkgolide - an overview | ScienceDirect Topics
The ginkgolides are a unique class of diterpenoids isolated from the ‘fossil’ tree Ginkgo biloba L. This tree is the only remaining species of the Ginkgoales, once a very large order, and its extreme botanical position is matched by the unusual chemistry of its constituents.
Ginkgolides and Their Derivatives: Synthetic and Bioorganic Studies
The isolation of ginkgolides from Ginkgo biloba extracts represents the main source of these trilactones for all synthetic, structural, and biological studies. However, some ginkgolides are more abundant in the extracts than others.
Ginkgolide - an overview | ScienceDirect Topics
The ginkgolides are a unique class of diterpenoids isolated from the ‘fossil’ tree Ginkgo biloba L. This tree is the only remaining species of the Ginkgoales, once a very large order, and its extreme botanical position is matched by the unusual chemistry of its constituents.
Ginkgo wetenschappelijk bekeken - Mens en Gezondheid
De ginkgolides zijn de meest krachtige en selectieve PAF (Platelet-Activating Factor)-antagonisten die er tot nu toe gevonden zijn. PAF is een sterk werkzame lichaamseigen stof die een rol speelt in veel pathologische situaties.
Exploring the multifaceted role of ginkgolides and bilobalide from
Ginkgolides A, B, and C, and bilobalide have unique pharmacological properties, including anti-inflammatory, antioxidant, antitumor, and neuroprotective effects. Importantly, they exhibit promise in tackling metabolic diseases, such as dyslipidemia and obesity-related complications.
Neuroregulatory role of ginkgolides | Molecular Biology Reports - Springer
The neuroregulative properties of ginkgolides include the conditioning of neurotransmitters action, e.g., glutamate or dopamine. Besides, natural compounds induce the inhibition of platelet-activating factors (PAF). Furthermore, ginkgolides influence the inflammatory process.
The Potential of Ginkgo biloba as a Source of Biologically Active ...
The terpene trilactones present in ginkgo, including ginkgolides A, B, C and bilobalide, correspond, inter alia, to its anti-epileptic effect on neurons within the brain’s hippocampus, improving memory and learning ability and ameliorating neuronal damage.
Ginkgolide - an overview | ScienceDirect Topics
Ginkgolides are diterpenoid trilactone-containing unique C20 lactone cage molecules that are the main principles from the slow-growing Ginkgo biloba L. (especially from leaf part), which are from gymnospermous tree, species in the division ginkgophyta, and a single surviving species belonging to the family of ginkgoaceae in a class of ...
Therapeutic promises of ginkgolide A: A literature-based review
Ginkgolide A is a highly active platelet activating factor antagonist cage molecule which was isolated from the leaves of the Ginkgo biloba L. It is known for its inflammatory and immunological potentials. This review aims to sketch a current scenario on its therapeutic activities on the basis of sc …
Biosynthesis pathways of ginkgolides - PMC
This review focuses on the biosynthetic pathways of ginkgolides, the enzymes related to the biosynthesis of the ginkgolides, the genes encoding the enzymes cloned from the ginkgo, and the factors influencing the production of ginkgolides in cell cultures.
Ginkgolide - an overview | ScienceDirect Topics
Ginkgolides are diterpenoid trilactone-containing unique C 20 lactone cage molecules that are the main principles from the slow-growing Ginkgo biloba L. (especially from leaf part), which are from gymnospermous tree, species in the division ginkgophyta, and a single surviving species belonging to the family of ginkgoaceae in a class of ...
Identification of a central regulator of ginkgolide biosynthesis in
Ginkgolides are secondary metabolites unique to Ginkgo biloba with the potential to prevent and treat cardiovascular and cerebrovascular diseases. Although the biosynthetic pathways of ginkgolides have been partly uncovered, the mechanism regulating their biosynthesis is still largely unknown.
Total Synthesis of Ginkgolide C and Formal Syntheses of Ginkgolides A ...
The highly complex molecular architecture of ginkgolides, combined with their remarkable biological profile, provides a unique platform for the development of new strategies and methods. Herein, we reported the first total synthesis of ginkgolide C and the formal syntheses of ginkgolides A and B.
Frontiers | Role of Ginkgolides in the Inflammatory Immune Response of ...
Ginkgolides have several different biological effects including inhibiting platelet aggregation, preventing apoptosis and oxidation, providing nutrition to nerves, and regulating neuroimmunity.
Role of Ginkgolides in the Inflammatory Immune Response of Neurological ...
Ginkgolides are natural PAFR antagonists that selectively and competitively antagonize PAF-induced platelet aggregation (Gui et al., 2007). It is well established that PAF signaling plays a pivotal role in the initiation and progression of inflammatory and thrombotic reactions, as well as in the cross talk between them (Stafforini et al., 2003).
Ginkgolides and bilobalide: Their physical, chromatographic and ...
Ginkgolides A, B, C, J, K, L and M and bilobalide are rare terpene trilactones that have been isolated from leaves and root bark of the Chinese tree Ginkgo biloba. The structures of the highly oxidized ginkgolides were independently elucidated in the 1960s by the groups of Nakanishi and Sakabe.
Ginkgolide - an overview | ScienceDirect Topics
Ginkgolides are pharmacologically-active diterpenes found in Ginkgo biloba (Ginkgoaceae), which have been widely reported to have several pharmacological properties, including anti-inflammatory effects; for example, Ginkgolides A–C, J and M (Fig. 4).